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Higher education - University degrees
The first higher education courses in blood transfusion in France were delivered in 1975 by the INTS. A decree implemented in 1976 indeed set forth the DUTS (Higher Degree in Blood Transfusion) as a joint diploma from Pierre et Marie Curie University and the "French National Centre of Blood Transfusion" which became the INTS in 1994. The INTS pursues its initial teaching assignment in collaboration with several universities. More specifically, these universities, in conjunction with the INTS, offer a Higher integrated curriculum in blood transfusion (CIUTS).
Initial curricula in blood transfusion implemented by these Universities :

  • René Descartes - Paris V
  • Pierre et Marie Curie - Paris VI
  • Denis Diderot - Paris VII
  • Jules Verne – Amiens

These curricula are delivered in collaboration with the teachers of the previously quoted universities, and those from Paris XI – Paris XII – Paris XIII - Bordeaux II - Lille II – Nantes – Rennes I – Saint Etienne – Strasbourg– Versailles Universities as well.

Also in collaboration with teachers from the following associated structures : Ecole d’Application du Service de Santé des Armées (Administration school for the healthcare of armed forces) – Centre de Transfusion Sanguine des Armées (Blood transfusion centre of armed forces)– Ecole des Hautes Etudes en Santé Publique (School for higher public healthcare) – Agence Française de Sécurité des Produits de Santé (French agency for health product safety) – Institut de Veille Sanitaire (National institute for public health surveillance) – Laboratoire Français du Fractionnement et des Biotechnologies (French laboratory for fractionation and biotechnologies) – Assistance Publique Hôpitaux de Paris (Public welfare Paris hospitals) – Assistance Publique Hôpitaux de Marseille (Public welfare Marseille hospitals) - Direction Générale de la Santé (National health executive) – Institut National de la Santé et de la Recherche Médicale (National institute for health and medical research) – Etablissement Français du Sang (French blood establishment) – Agences Régionales de Santé (Regional health and welfare bureaux in Auvergne, Bretagne, Franche-Comté, Ile de France, Languedoc-Roussillon, Lorraine, Nord, Pas de Calais, Normandie, PACA, Pays de Loire, Picardie).

This curriculum is composed of 25 modules (M1 to M25) as follows:

Higher degrees
Modules
Transfusion Technology Capacity (CTT)
1,2,3,4,5,6,7,8,9,10,11,12,13,
14,16,17,18,19,20,21,23,24,25
Specialized degree in hæmobiology-transfusion (DESC)
1 to 25
Blood Transfusion University Degree (DUTS)
1 to 25
Inter-university degree for ‘therapeutic principles in transfusion technology’ (D3T)
1,3,8,10,11
University degree for quality and safety of blood components (DUQSPS)
1 to 21
University degree for Continuous Improvement and Quality implementation (DFQ)
4 specific modules
 

The INTS is involved and responsible for the pedagogical and logistic organization of the curricula it delivers.

Diplomas can be picked up directly at the University.

C.I.U.T.S.
The CIUTS (Higher integrated curriculum in blood transfusion) is unique in Europe. It is delivered by the INTS (French national institute of blood transfusion) in collaboration with different universities.
This curriculum is composed of 25 modules. According to his/her objectives and the number of modules he/she is registered in, the student is likely to apply to one of the following higher degrees:
D.U.T.S. – Blood Transfusion University Degree
Coordinator : Prof. Philippe ROUGER (Paris VI University)
This Doctorate-level university degree is delivered by the Paris VI University. Courses are coordinated by the INTS and are meant for future executives, MDs, PharmDs and scientists from the EFS (French Blood Establishment) or associated laboratories.
C.T.T. – Transfusion Technology Capacity
Coordinator : Prof. Philippe ROUGER (Paris VI University)
This national degree allows MDs, non resident and consequently not having passed the DES or DESC, to bear responsibilities in transfusion, in blood transfusion establishments or hospitals.
D.E.S.C. – Specialized degree in Haemobiology-Transfusion
Coordinator : Prof. Philippe ROUGER (Paris VI University)
This national degree is a vocational curriculum meant for residents or former residents. The DESC curriculum encompasses the DUTS. Duration : 2 years, of which 1 as a resident.
D.3T. - Inter-university degree for ‘therapeutic principles in transfusion technology’
Coordinators : Prof. Philippe ROUGER (Paris VI University), Prof. Jean-Luc WAUTIER (Paris VII University), Prof. Jean-Jacques LEFRERE (Amiens University)
This degree has been implemented in 2004-2005, in substitution to the DUMT (University Degree of Transfusion Medicine), in conjunction between Paris VI, Paris VII and Picardie Jules Verne – Amiens Universities. It is meant for the MDs or PharmDs in charge of a blood repository or responsible for Haemovigilance inside their establishment.
D.F.Q. - University degree for Continuous Improvement and Quality implementation
Coordinator: Dr. François TRAPADOUX
Initiated since the 2010-2011 university new term, this 140-hour graduating curriculum is meant for biologists, quality managers or their staff, wishing to get trained and reach for a practical experience of the laboratory-implemented ISO 19011, 15189, 17025, 22870 accreditation, securing its permanence thanks to technical and quality evaluations as imposed by the regulations in force and the COFRAC (French accreditation institution) policies.
Applications to register (cover letter + detailed resume) should be sent to :
Professor Philippe ROUGER - INTS – 6 rue Alexandre Cabanel – F-75739 Paris Cedex 15
Information : Secretariat – Education & Training Dept. : +33 (0)1 44 49 30 23
D.U.Q.S.P.S. - University degree for quality and safety of blood components
Coordinator : Prof. Dominique VIGNON (Paris V University)
Meant for MDs and PharmDs, this curriculum aims at teaching not only the bases in transfusion safety and quality but also an in-depth knowledge in blood derivatives. It is set up by Paris V University – Prof. Dominique Vignon, d.vignon@hopital-foch.org
CIUTS : 2010 – 2011 syllabus
The following chart displays modules as part of the academic curriculum of each degree.
M1 - M2 - M3 - M4 - M5 - M6 - M7 - M8 - M9
M10 - M11 - M12 - M13 - M14 - M15 - M16 - M17 - M18 - M19
M20 - M21 - M22 - M23 - M24 - M25
Oct. 22, 2010
Module 1 (M1)
CTT/D3Ti/DESC/DUTS/DUQSPS
Blood transfusion organization in France and in Europe

09h00-11h30

Organization of the French transfusion and role of the different instances

Prof. Ph. Rouger

11h30-13h00

Organization in Europe - Social-economy in blood transfusion

Prof. Ph. Rouger

14h00-15h30

Implementation of European regulations in French blood establishments and healthcare facilities

Dr. M. Carlier

15h30-17h00

Stakes of HPST law in transfusion safety

Dr. J.J. Cabaud
TOP
Oct. 29, 2010
Physiology of blood cells
Module 2 (M2)
CTT/DESC/DUTS/DUQSPS
Hematopoiesis, erythrocyte physiology and basic immunology

09h00-11h00

Hematopoïesis

Dr. F. Norol

11h00-12h30

Erythrocyte physiology

Dr. M. Rossignol

14h00-17h00

Basic immunology : antigens and antibodies

Dr. F. Cognasse
TOP
Nov. 5, 2010
Immuno-Hematology (1)
Module 3 (M3)
CTT/D3Ti/DESC/DUTS/DUQSPS
Erythrocyte blood groups : structure and roles

09h00-12h30

ABO system and associates

Dr. V. Van Huffel

14h00-17h00

RH, Kell, Duffy, Kidd, MNS… systems

Dr. V. Van Huffel

17h00-18h30

The allo-immunization

Dr. T. Peyrard
TOP
Nov. 12, 2010
Immuno-Hematology (2)
Module 4 (M4)
CTT/DESC/DUTS/DUQSPS
Immuno-Hematology Techniques and investigations

09h00-13h00

Immuno-Hematology techniques : clusters - RAI - TCD - Elution - Compatibility and interpretation

Dr. B.N. Pham

14h00-15h30

What to do when a transfusion haemolytic accident occurs in a laboratory

Dr. C. Krause

15h30-17h00

Autoimmune hemolytic anemia – What treatment should be envisaged ?

Dr. C. Krause
TOP
Nov. 19, 2010
Immuno-Hematology (3)
Module 5 (M5)
CTT/DESC/DUTS/DUQSPS
Molecular biology & Immuno-hematology

09h00-13h00

Molecular approach of blood groups : structure and roles

J.P. Cartron

14h00-15h30

Erythrocyte blood groups : What’s up ?

Dr. B.N. Pham

15h30-18h00

Hemolytic disease of the new-born

Drs. A. Mailloux &
Y. Brossard
TOP
Nov. 26, 2010
Donation : medical aspects
Module 6 (M6)
CTT/DESC/DUTS/DUQSPS

09h00-11h00

Interview, questionnaire, information

Dr. B. Pelletier

11h00-13h00

Medical examination, adverse reactions

Dr. B. Pelletier

14h00-15h30

Psycho-sociological approach of the donor

Dr. B. Danic

15h30-16h30

Sociological aspects of blood donation in France : Ethics and regulations

Dr. B. Danic

16h30-18h00

Epidemiology of infectious reagents and residual risk

Dr. J. Pillonel
TOP
Dec. 3, 2010
Blood collection – Preparation of labile blood products (1)
Module 7 (M7)
CTT/DESC/DUTS/DUQSPS

09h00-11h00

Aphaeresis techniques

Dr. C. Coffe

11h00-13h00

Donation types, including autologous donation

Dr. G. Woimant

14h00-16h00

Preparation of cell labile blood products

Dr. R. Tardivel

16h00-18h00

Plasma components & indications (raw material included)

Prof. M. Joussemet
TOP
Dec. 17, 2010
Preparation of labile blood products (2) – Distribution & delivery (1)
Module 8 (M8)
CTT/D3TI/DESC/DUTS/DUQSPS
Labile blood products

09h00-13h00

Quality control and conservation of labile blood products : red cell and platelet concentrates, therapeutic plasma

Dr. S. Bégué
Distribution

14h00-15h30

Distribution – Delivery of labile blood products

Dr. A. François

15h30-17h00

Practical aspects

Dr. A. François

17h00-18h30

Final bedside controls

Dr. C.Trophilme
TOP
Jan. 7, 2011
Preparation of labile blood products (3) – Blood-transmissible diseases (1)
Module 9 (M9)
CTT/DESC/DUTS/DUQSPS

09h00-10h00

Preparation of labile blood products and prevention of certain transfusion adverse reactions (non-hemolytic fever, allergy, GVH)

Dr. R. Tardivel

10h00-12h00

Prevention against blood-transmissible CMV and B19 Parvovirus

Prof. D. Vignon

12h00-13h00

Pathogen reduction in therapeutic plasma

Dr. Y. Piquet

14h00-15h00

Platelet physiology

Prof. J.P. Cazenave

15h00-16h00

Pathogen reduction in platelet concentrates

Prof. J.P. Cazenave

16h00-17h00

Pathogen reduction in red cell concentrates

Prof. J.P. Cazenave
TOP
Jan. 14, 2011
Blood-transmissible infectious agents (2)
Module 10 (M10)
CTT/D3Ti/DESC/DUTS/DUQSPS

09h00-11h00

Blood-transmissible parasite diseases : Paludism, Chagas disease, etc ...

Dr. M. Thellier

13h00-14h30

Bacterian risk and prevention

Dr. P. Morel

14h30-16h00

Hepatites virus

Dr. S. Laperche

16h00-18h00

Retrovirus – HTLV

Dr. S. Laperche
TOP
Jan. 21, 2011
Blood-transmissible infectious agents (3)
Distribution & delivery (2)
Module 11 (M11)
CTT/D3TI/DESC/DUTS/DUQSPS
Blood-transmissible diseases

09h00-13h00

Emerging pathogens and ATNC (non-conventional transmissible viruslike agents)

Prof. J.J. Lefrère
Delivery of labile blood products

14h00-16h00

Transfusion of rare phenotypes. What is the role of the CNRGS ?

Dr. T. Peyrard

16h00-18h00

Transfusional advice

Dr. A. François
TOP
Jan. 28, 2011
Biological qualification of donations - Automation
Module 12 (M12)
CTT / DESC/DUTS
Automation

9h00-13h00

Automation and IT aspects in transfusion

D. Dernis
J.P. Becquart
Biological qualification of donations

14h00-15h00

Organization

Dr. M.H. Elghouzzi

15h00-16h30

Serological techniques

Dr. M.H. Elghouzzi

16h30-18h00

VGS (Viral Genomic Screening)

Dr. M.H. Elghouzzi
TOP
Feb. 4, 2011
Quality
Module 13 (M13)
CTT/DESC/DUTS/DUQSPS

09h00-12h30

Curriculum : pending

14h00-16h00

16h00-17h00

TOP
Feb. 11, 2011
Blood derivatives
Module 14 (M14)
CTT/DESC/DUTS/DUQSPS
Plasma fractionation

09h00-11h00

Human plasma fractionation : bases

Dr. J.J. Huart

11h00-12h30

Production of blood derivatives

Dr. J.J. Huart

14h00-16h30

Indications of human immunoglobulins

Prof. L. Mouthon

16h30-18h00

Albumin indication

Dr. T. Rackelboom
TOP
Feb. 18, 2011
Hemostasis
Module 15 (M15)
DESC/DUTS/DUQSPS

09h00-13h00

Blood derivatives : Factor VIII, Factor IX, Factor Willebrand and others : preparation and use

Dr. Ch. Rothschild

14h00-16h00

Clotting inhibitors, antithrombin III, protein C, protein S and protease inhibitors

Dr. M.H. Horellou

16h00-18h00

Other plasma derivatives : fibrin glue, rVIIa (Factor VII activated) ...

Dr. M.H. Horellou
TOP
Feb. 25, 2011
Vigilances
Module 16 (M16)
CTT/DESC/DUTS/DUQSPS

09h00-13h00

Haemovigilance from the blood donor to the labile blood product recipient: adverse reactions and transfusion chain incidents

Dr. F Ferrer-Le Coeur

14h00-15h00

Pharmacovigilance

Dr. J. Berthou

15h00-16h00

Materiovigilance

Dr. C. Fretz

16h00-18h00

Reactovigilance & Biovigilance

Dr. B.N. Pham
TOP
March 4, 2011
Transfusion Medicine (1)
Module 17 (M17)
CTT/DESC/DUTS/DUQSPS
Transfusion of red cell concentrates

09h00-11h00

Hemoglobinopathies

Prof. F. Galacteros

11h00-13h00

Other haematological indications

Dr. B. Boval

15h00-16h00

Paediatric indications

Dr. D. Boyeldieu

16h00-18h00

Other non-haematological indications

Prof. A. Lienhart
TOP
March 11, 2011
Transfusion Medicine (2)
Module 18 (M18)
CTT/DESC/DUTS/DUQSPS
Transfusion of platelet concentrates

09h00-11h00

Indications of platelet concentrates

Dr. G. Andreu

11h00-13h00

Transfusion indications of transplanted patients and patients with chimiotherapy

Dr. F. Lefrère
Transfusion therapeutics

14h00-16h00

Platelet immunology and fetal and neonatal thrombopaenia

Dr. C. Kaplan

16h00-18h00

Substitutes to labile blood products

Prof. J.L. Wautier
TOP
March 18, 2011
Transfusion Medicine (3)
Module 19 (M19) (suite)
CTT/DESC/DUTS/DUQSPS
Transfusion therapeutics

09h00-10h30

Erythropoietin : fundamentals

Prof. N. Casadevall

10h30-12h30

Erythropoietin & priority blood sparing Per- and postsurgical blood retrieval Blood waste calculations

Dr. M. Rossignol

14h00-15h30

Non-pharmacological blood sparing techniques

Prof. M. Samama

15h30-18h00

Normovolemic haemodilutions: useful or not ?
Massive transfusion
Transfusion in surgery & synthesis

Prof. Y. Ozier
TOP
March 23, 2011
Histocompatibility (1)
Module 20 (M20)
CTT/DESC/DUTS/DUQSPS
Histocompatibility - Transplantations

09h00-13h00

From the gene to the molecule. MHS (Major Histocompatibility System) function

L. Hallé

14h00-15h30

Antibody investigation and identification, cross match. Searching for compatible donors with the single antigen techniques.

L. Absi

15h30-17h30

Transplantation-oriented blood typing : technique options, selection of the best donor

K. Gagne
TOP
April 1, 2011
Histocompatibility (2)
Module 21 (M21)
CTT/DESC/DUTS/DUQSPS

09h00-10h30

Mechanisms controlling the immune response in hematopoietic stem cell transplantations

Prof. A. Buzyn

10h30-12h30

Mechanisms controlling the immune response in organ transplantations

Dr. A. Devys

14h00-17h00

What is the role of non classical HLA molecules in innate and adaptive immunity ?

Dr. C. Retière
TOP
April 8, 2011
Biotechnologies
Module 22 (M22)
DESC/DUTS/DUQSPS

09h00-13h00

Blood transfusion-related molecular biology

Dr. J.P. Cartron

14h00-16h30

Biological diagnosis-related molecular biology

Prof. M. Delpech

16h30-17h30

Biotechnology-derived components and reagents

Prof. Ph. Rouger
TOP
April 15, 2011
Cell and tissue therapies (1)
Module 23 (M23)
CTT/DESC/DUTS/DUQSPS

09h00-11h00

Cell therapy : technology – regulations

Dr. P. Bourin

11h00-12h30

Hematopoietic stem cell transplantation (treatment or ex-vivo expansion included : techniques and indications)

Dr. H. Rouard

12h30-13h30

Specificities of placenta blood transplantation

Dr. R. Traineau

14h30-16h00

Production of mature red cells in vitro

Pr L. Douay

16h00-18h00

GVH - GVL – residual disease: biology and clinic

Pr J.P. Vernant
TOP
April 22, 2011
Cell and tissue therapies (2), cytokines and blood transfusion, synthesis of transfusion-related adverse reactions
Module 24 (M24)
CTT/DESC/DUTS

09h00-11h00

Organ and tissue transplantations in France

Dr. M. Thuong

11h00-13h00

Cytokines and transfusion (other than erythropoietin)

Prof. O. Garraud

14h00-18h00

Immediate adverse reactions in recipients - synthesis : hemolytic accident, non hemolytic fever, allergy, overload, TRALI, post-transfusion purpura, GVH

Dr. G. Andreu
TOP
April 29, 2011
Administration and finance management in blood transfusion establishments
Module 25 (M25)
CTT/DESC/DUTS

09h00–10h30

Liability in blood transfusion

Dr. V. Van Huffel

10h30-12h00

AFSSAPS (French agency for health product safety - inspections)

C. Guiol

13h30-14h30

Administration of a regional French Blood Establishment

K. Pitoy

14h30-16h00

Management of a regional French Blood Establishment

K. Pitoy
TOP
D3T :
Blood repository option : 14 – 18 Feb. 2011
Haemovigilance option : 21 to 25 Feb. 2011
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